FORMULASI MULTIGRANUL SALUT FILM DALAM KAPSUL UNTUK PELEPASAN OBAT SECARA TERKENDALI

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  • Wira Brata Universitas Pancasila
Keywords: formulasi, lepas terkendali, multigranul, salut film

Abstract

Penelitian ini tentang formulasi multigranul salut film dalam kapsul yang bertujuan memberikan pelepasan obat secara terkendali dengan bahan berkhasiat gliseril guaikolat. Multigranul yang digunakan terdiri dari 3 jenis granul, yaitu: 1 jenis granul tidak disalut sebagai dosis awal obat, dan 2 jenis granul salut film dengan beda konsentrasi penyalutnya. Penyalut film yang dgunakan adalah hidroksipropil metilselulosa ftalat dengan konsentrasi: 1%, 5%, 10%, dan 15%. Granul dibuat menggunakan Metode Panci Penyalut. Bobot granul untuk tiap kapsul adalah 450 mg mengandung gliseril guaiakolat sebanyak 100 mg untuk dosis awal dan 200 mg untuk dosis penjagaan berupa variasi 2 macam granul salut film. Kemudian dibuat formula-formula kapsul dengan kombinasi dari multigranul dan dilakukan pengujian pelepasan obat. Hasil penelitian menunjukkan bahwa: kapsul Formula 1 dan Formula 6 tidak memberikan profil pelepasan obat secara terkendali. Kapsul Formula 2 memberikan profil pelepasan obat secara terkendali selama 8 jam. Kapsul Formula 3 memberikan profil pelepasan obat secara terkendali selama 12 jam dengan jumlah obat terlarut yang terbesar, yaitu: 92,9%. Kapsul Formula 4 dan Formula 5 memberikan pelepasan obat secara terkendali selama 12 jam dengan jumlah obat terlarut 91,5% dan 89,2%. Kesimpulan diperoleh formula terbaik untuk pelepasan terkendali dari multigranul dalam kapsul yang paling lama secara uji disolusi.

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Published
2021-12-12
How to Cite
Brata, W. (2021). FORMULASI MULTIGRANUL SALUT FILM DALAM KAPSUL UNTUK PELEPASAN OBAT SECARA TERKENDALI. Jurnal Farmamedika (Pharmamedika Journal), 6(2), 59-68. https://doi.org/10.47219/ath.v6i2.128