FORMULASI DAN AKTIVITAS ANTIBAKTERI SEDIAAN GEL HAND SANITIZER DARI EKSTRAK ETANOL BIJI MANGGA HARUM MANIS ( Mangifera indica L.) TERHADAP Escherichia coli DAN Staphylococcus aureus

  • Harry Noviardi Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
  • Herson Cahaya Himawan Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
  • Rina Anggraeni Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
Keywords: Antibacterial, E. coli, Hand Sanitizer, Mango Seed, S. aureus

Abstract

Mangifera indica L. is a plant that has antibacterial activity. One of the plant‟s parts that has antibacterial activity on mango is the seed. Natural antibacterial content in the form of tannins contained in ethanol extract of Harum Manis mango seed is considered being effective towards Escherichia coli and Staphylococcus aureus bacteria, which are the main cause bacteria in diarrhea and other skin infections. The objective of this study is to obtain a good and effective formulation to remove Escherichia coli and Staphylococcus aureusbacteria in order to produce natural hand- made antiseptic gel preparations. The diameter of clear zone produced by gel preparation of hand sanitizer ethanol extract of mango seed on Escherichia coli bacteria with gel concentration of 2; 2.5 and 5% respectively - 10.86, 1.74, and 13.15 mm, while on a positive control, it is 7.47 mm. On the other hand, the diameter of clear zone in Staphylococcus aureus with gel concentration of 2; 2.5 and 5% respectively - 10.14, 10.58, and 12.83 mm, while on the positive control, it is 7.43 mm. Based on Anovaone way test followed by Duncan test show a significant difference (significant effect) between the concentration. It can be concluded that the preparation of 70% ethanol extract gel having antibacterial effectiveness towards Escherichia coli and Staphylococcus aureus and effective gel preparation evaluation results are at 2,5% concentration

References

[1] Ginanjar, E.F., Retnaningrum, E., Septriani, N. I., Octaviani, A., Wiyati, D.





[4]

from Mango Kernels (Mangifera indica L.).Applied and Environmental Microbiology.77(7): 2215–2223


Prihandani,S.,Noor,S.,Andriani.,Poeloe ngan,M.,2016.Efektivitas Ekstrak Biji Mangga Harumanis terhadap Staphylococcus aureus, Bacillus subtilis, Shigella sp., dan Escherichia coli.Jurnal Veterineer. 17:45-50.
A. T. M., dan Rosrinda, E., 2010,Handy Gel Carrota Hasil Fermentasi Daun Wortel Sebagai Antibakteri Penyebab Penyakit Kulit, Yogyakarta prosiding Seminar Nasional Biologi,Fakultas Biologi Universitas Gadjah Mada,1169. [2] Legesse, M. B., Shimelis, A. E. 2012. Functional and physicochemical properties of mango seed kernels and wheat flour and their blends for biscuit production.African Journal of Food Science and Technology3: 193–203.

[3] Engels C, Andreas, S., Michael GG. 2011. Inhibitory Spectra and Modes of Antimicrobial Action of Gallotannins
[5] Sumiyati,I., 2014.Efektivitas Ekstrak Padina Australis sebagai Anti Bakteri Eschericia coli penyebab Diare.Bogor.Universitas Pakuan Bogor.

.[6] Jawetz., Melnick dan Adelberg.2007. Mikrobiologi Kedokteran Jawetz, Melnick,& Adelberg, Ed.23,Translation of Jawetz, Melnick, and Adelberg’s Medical Microbiology,23thEd. Hartanto, H., et al.Editor.Jakarta: EGC.

[7] Tunjungsari,D.2012.Formulasi sediaan gel ekstrak etanolik buah mahkota dewa (Phaleria macrocarpa (Scheff) Boerl) dengan basis carbomer Surakarta.Universitas Muhammadiyah Surakarta.

[8] Ansel, H.C. 1989. Pengantar Bentuk Sediaan Farmasi, diterjemahkan oleh Farida Ibrahim Edisi 1V. Jakarta: UI- Press.

[9] Khaerunisa,R.,Priani,S., dan Lestari,F., 2015 Formulasi dan uji efektivitas sediaan gel antiseptic tangan mengandung ekstrak etanol daun mangga harumanis (Mangifera indica L.).Bandung.Universitas Islam Bandung
Published
2018-06-12
How to Cite
Harry Noviardi, Herson Cahaya Himawan, & Rina Anggraeni. (2018). FORMULASI DAN AKTIVITAS ANTIBAKTERI SEDIAAN GEL HAND SANITIZER DARI EKSTRAK ETANOL BIJI MANGGA HARUM MANIS ( Mangifera indica L.) TERHADAP Escherichia coli DAN Staphylococcus aureus . Jurnal Farmamedika (Pharmamedika Journal), 3(1), 1-9. https://doi.org/10.47219/ath.v3i1.20