• Sitaresmi Yuningtyas Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
  • Anna P. Roswiem Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
  • Erfina Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
Keywords: alpha-glucosidase, diabetes mellitus, Dillenia suffruticosa (Griff.) Martelli, simpur air leaves


Diabetes mellitus is a disorder of carbohydrate metabolism which characterized by hyperglycemia conditions. One of the mechanism from oral hypoglycemic drug is inhibition of α-glucosidase activity. Dillenia suffruticosa (Griff.) Martelli, known as "simpur air" has been used to treat diabetes mellitus. This study aims to determine the inhibition activity of α-glucosidase enzyme from water and ethanol extract simpur air leaves. Simpur air leaves extracted with water and ethanol 70% using maceration method. Parameter evaluated in this research were phytocemical screening and alpha glucosidase inhibiting (AGI) activity. The results showed that the active compounds in water and ethanol extracts were flavonoids, saponins and tannins. AGI activity in water extract from simpur air leaves at concentrations of 1%, 1.5% and 2% were 1.49%, 2.76% and 3.91%, respectively. AGI activity in ethanol extract from simpur air leaves at concentrations of 1%, 1.5% and 2% were 92.10%, 98.10% and 118.30%, respectively. While the AGI activity from glucobay were 99.50%. The optimum of AGI activity was in 1.5% ethanol extract. This AGI acivity which was not significantly different (α<0.05) from the 1% glucobay.


[1]. Armania, N., Yazan, L.S., Musa, S.N., Foo, J.B., Chan, K.W., Noreen, H. Hisyam, A.H., Zulfahmi, S., Ismail, M. 2013. Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest. J Ethnopharmacol 146 (2): 525- 535.

[2]. Brahmachari, G. 2011. Bio-flavonoids with promising antidiabeticpotentials: A critical survey. Opportunity, Challenge and Scope ofNatural Products in Medicinal Chemistry: 187-212.

[3]. Feng, J., Yang. X.W., Wang, R.F. 2011. Bio-assay guided isolation and identification of α-glucosidase inhibitors from the leaves of Aquilaria sinensis. Phytochemistry 72: 242-247.

[4]. Harborne, J.B. 1987. Metode Fitokimia, Penuntun Cara Modern Menganalisis Tumbuhan. Bandung: Penerbit ITB.

[5]. Hollander, P., Pi-Sunyer, X., Coniff, R.F. 1997. Acarbose in the treatment of type 1 diabetes. Diabetes care 20: 248-253.

[6]. Lai, Y.C., Chen, C.K., Tsai, S.F., Lee, S.S. 2012. Triterpenes as α-glukosidase inhibitors from Fagus hayatae. Phytochemistry 74: 206-211.

[7]. Lee, S.S, Lin, H.C., Chen, C.K. 2008. Acylated flavonol monorhamnosides, α- glukosidase inhibitors, from Machilus phillippinensis. Phytochemistry 69: 2347- 2353.

[8]. Mayur, B., Sandesh, S., Shruti, S., Yum, S. S. 2010. Antioxidant And α-Glucosidase Inhibitory Properties Of Carpesium Abrotanoides L. Journal Of Medicinal Plants Research. 4(15) : 1547-1553.

[9]. Patel, M.B., Mishra, S.M. 2012. Magnoflorine from Tinospora cordifolia stem inhibits α-glukosidase and is antigycemic in rats. J Funct Foods 4: 79- 86.

[10].Tadera, K., Minami, Y., Takamatsu, K., Matsuoka, T. 2006. Inhibition of α- glukosidase and α-amylase by flavonoids. J. Nutr. Sci Vitaminol 52: 149-153.

[11].The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. 2003. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26 (Suppl 1): 5- 20.
[12].Wang, H., Du, Y.J., Song, H.C. 2010. α- glukosidase and amylase inhibitory activities of guava leaves. Food Chem 123: 6-13.

[13].Wild, S., Roglic, G., Green, A., Sicree, R., King, H. 2004. Global prevalence of diabetes: estimates for the year 2000 and projections 2030. Diabetes Care 27 1047- 1053.
[14].Yazan, L.S., Armania N. 2014. Dillenia species: a review of the traditional uses, active constituents and pharmacological properties from preclinical studies. Pharm Biol(7): 890-897
How to Cite
Sitaresmi Yuningtyas, Anna P. Roswiem, & Erfina. (2018). AKTIVITAS INHIBISI α-GLUKOSIDASE DARI EKSTRAK AIR DAN ETANOL DAUN SIMPUR AIR (Dillenia suffruticosa (Griff.) Martelli) . Jurnal Farmamedika (Pharmamedika Journal), 3(1), 21-26. https://doi.org/10.47219/ath.v3i1.23