OPTIMASI WAKTU MASERASI SILDENAFIL SITRAT DALAM JAMU KUAT YANG BEREDAR DI BOGOR BARAT

  • Harry Noviardi Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
  • Bina Lohita Sari Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan
  • Muhamad Wildan Malik Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
Keywords: jamu kuat, maceration, optimization sildenafil citrate, time

Abstract

Herbal medicine is types traditional medicine that is consumed by people. One type of herbal medicine on the market is Jamu Kuat. According Indonesian Food and Drug Administration, herbal medicine can not contain chemical of drugs. But, Jamu Kuat on the market still found contain chemical of drug, that is sildenafil citrate. In previous research, analysis of sildenafil citrate in the Jamu Kuat has not been accompained by the optimization of extraction time.The aim of research is optimizing the time of maceration sildenafil citrate in Jamu Kuat circulating on the West Bogor. Sampling of Jamu kuat was used purpusive sampling. The sample macerated with constant stirring was used a magnetic stirrer with 560 rpm and analyzis with Thin Layer Chromatography and Spectrophotometry UV-Vis method. Results of the research show that there was 5 from 8 samples Jamu Kuat contained sildenafil citrate. Optimum times of maceration was 60-90 minutes in four samples, 120-150 minutes in one sample and contains sildenafil citrate 8.00-11.00% in four samples and 20.00-21.00% in one sample. The results was concluded there different optimal times for samples

References

[1] [BPOM] Badan Pengawas Obat dan Makanan. 2005. Peraturan Kepala Badan Pengawas Obat Dan Makanan Republik Indonesia Nomor HK.00.05.4.1380 Tahun 2005. Tentang Penerapan Pedoman Cara Pembuatan Obat Tradisional Yang Baik. Jakarta: BPOM. [2] [Depkes RI] Departemen Kesehatan Republik Indonesia. 2012. Peraturan Menteri Kesehatan Republik Indonesia Nomor 007 Tahun 2012 Tentang Registrasi Obat Tradisional. Jakarta : Depkes RI [3] Saragih, E.B. 2014. Analisis Kandungan Sildenafil Sitrat Dalam Pil Biru yang Dijual di Daerah Ciputat [skripsi]. Jakarta : Universitas Islam Negeri Syarif Hidayatullah Jakarta.
[4] [BPOM] Badan Pengawas Obat dan Makanan.2015. Hasil Pengawasan Obat Tradisional dan Suplemen Kesehatan Stamina Pria Mengandung Bahan Kimia Obat. http://www.pom.go.id/mobile/index.php/view/pers/276.html diakses pada tanggal 25 Februari Pukul 10.34 WIB [5] Tjay, T.H., Rahardja, K. 2008. Obat-Obat Penting: Khasiat, Penggunaan dan Efek-efek samping. Edisi VI. Jakarta: Elex Media Komputindo. [6] Sarigih, A.T.W, Kusuma A.M, Utami, P.I. 2010. Analisis Sildenafil Sitrat dalam Jamu Tradisional Kuat Lelaki Merk A dan B dengan Metode Kromatografi Cair Kinerja Tinggi. Pharmacy. 7(2): 24-32
[7] Purnama, L.D. 2005. Analisis Sildenafil Sitrat dalam Jamu Kuat secara Kromatografi Lapis Tipis [skripsi]. Depok : Universitas Indonesia. [8] Audu, S.A, Ogunbameru, W, Sani, M.A, Abdulraheem R.O, Abdulhareem R.B. 2012. Quantitative Determination of Sildenafil Citrate in Commercial Tablet Dosage Form Marketed in Maiduguri Metropolitan Council (MMC).IRJP. 3(9): 91-93
[9] Dinas Pemerintah Kota Bogor. 2016. Profil Kecamatan dan Kelurahan Kota Bogor. http://www.profilwilayah.kotabogor.go.id/index.php/bogor-barat diakses pada tanggal 5 April 2016 Pukul 04.53 WIB [10] Mahmoudian, M. 2005. Sildenafil Determination in Various Matrices : A Review. IJPT. 4(2) : 72-75. [11] Watson, D.G. 2005. Pharmaceutical Analysis. Edisi II. Glasglow : University of Strathclyde. [12] Gritter, R.J., J.M. Bobbit, dan A. E. Scwartung, 1991. Pengantar Kromatografi. Ed.2, terjemahan Kosasih Padmawinata. Bandung: Penerbit ITB. [13] Stahl, E. 1985. Analisis Obat secara Kromatografi dan Mikroskopi diterjemahkan oleh Kosasih Padmawinata dan Iwang Soediro. Bandung : Institut Teknologi Bandung. [14] Gandjar, I.G, Gandjar & Rohman, A. 2007. Kimia Farmasi Analisis. Yogyakarta: Pustaka Pelajar. [15] Day, R.A dan Underwood. 1991. Analisis Kimia Kuantitatif. Alih Bahasa : Soendoro dkk. Jakarta: Erlangga [16] Harmita, A. 2006. Analisis Fisikokimia. Jakarta : Departemen Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia. [17] Skoog, West Holler. 2002. Fundamental of Analytical Chemistry, 8th ed. New York: Thomas Brooks Cole. [18] Treyball, R.E. 1980. Mass Transfer Operations, 3rd Edition. New York: McGraw-Hill Companies, Inc.
Published
2016-12-12
How to Cite
Harry Noviardi, Bina Lohita Sari, & Muhamad Wildan Malik. (2016). OPTIMASI WAKTU MASERASI SILDENAFIL SITRAT DALAM JAMU KUAT YANG BEREDAR DI BOGOR BARAT. Jurnal Farmamedika (Pharmamedika Journal), 1(2), 92-100. https://doi.org/10.47219/ath.v1i2.55