EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN SEPSIS NEONATUS DI RAWAT INAP PERINATOLOGI RSUD TARAKAN
DOI:
https://doi.org/10.47219/ath.v7i2.158Abstract
Sepsis neonatus atau sepsis pada bayi baru lahir adalah sindrom klinis akibat infeksi aliran darah yang bersifat invasif, yang terjadi dalam satu bulan pertama kehidupan dan ditandai dengan adanya mikroorganisme patogen dalam darah, cairan sumsum tulang atau air kemih. Mikroorganisme patogen tersebut dapat berupa bakteri, virus, jamur, dan protozoa. Penelitian ini bertujuan untuk mengetahui ketepatan penggunaan antibiotik dengan kriteria tepat jenis obat, tepat dosis, dan tepat lama pemberian yang diberikan pada pasien sepsis neonatus di Rawat Inap Perinatologi RSUD Tarakan periode Mei sampai Juli 2017. Jenis penelitian ini adalah deskriptif dan pengambilan data dilakukan secara retrospektif terhadap data rekam medis seluruh pasien diagnosis sepsis neonatus. Sampel penelitian ini adalah 75 pasien sepsis neonatus yang memenuhi kriteria inklusi dan eksklusi penelitian. Evaluasi ketepatan penggunaan antibiotik dilakukan dengan melihat standar pengobatan sepsis neonatus berdasarkan panduan sepsis pada neonatus RSUD Tarakan (2016), IDAI (2009), WHO (2012), Sepsis Management Guidelines for Neonates (2016), Neonatology Sixth Edition (2009), dan British National Formulary for Children (2014). Hasil penelitian menunjukkan bahwa analisis ketepatan penggunaan antibiotik pada pasien sepsis neonatus di Rawat Inap Perinatologi RSUD Tarakan ketepatan jenis obat sebanyak 91,18%, ketepatan dosis sebanyak 91,18%, dan ketepatan lama pemberian sebanyak 92,94%.
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(2) Kumar PDV, Mohan J, Rakesh PS, Prasad J, Joseph L. 2017. Bacteriological Profile of Neonatal Sepsis in A Secondary Care Hospital in Rural Tamil Nadu, Southern India. Dalam: Journal of Family Medical and Primary Care. Departement of Pediatrics Christian Fellowship Hospital, Departement of Pediatrics Chiristian Medical College, Departement of Community Medicine Chiristian Medical College, India. Hlm 1.
(3) Radji M. 2016. Mekanisme Aksi Molekuler Antibiotik dan Kemoterapi. Penerbit Buku Kedokteran EGC. Jakarta. Hlm. 2-17.
(4) Williams PCM, Isaacs D, Berkley JA. 2017. Antimicrobial Resistance among Children in sub-Saharan Africa. Dalam: Journal Lancet of Infectious Disease. PubMed. Elsevier. Hlm. 1.
(5) Hadi U, Duerink DO, Lestari ES, Nagelkerke NJ, Keuter M, Huis IVD, Suwandojo E, Rahardjo E, Van DBP, Gyssens IC. 2008. Audit of Antibiotic Prescribing in Two Governmental Teaching Hospitals in Indonesia. Dalam: Journal of Microbiology and Infectious Disease Vol 14. Department of Internal Medicine Dr Soetomo Hospital-School of Medicine Airlangga University, Indonesia. Hlm. 698-707.
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(13) Lestari DA, Sarumpaet SM, Hiswani. 2011. Karakteristik Penderita Sepsis Neonatorum Rawat Inap di RSUD Dr. Pirngadi Medan Tahun 2010-2011. Dalam: Jurnal Fakultas Kesehatan Masyarakat USU. Universitas Sumatera Utara. Hlm 1-10.
(14) Yadav NS, Sharma S, Chaudhary DK, Panthi P, Pokhrel P, Shrestha A, Mandal PK. 2018. Bacteriological Profile of Neonatal Sepsis and Antibiotic Susceptibility Patterns of Isolates Admitted at Kanti Children’s Hospital, Kathmandu, Nepal. Dalam: Journal of BMC Research Notes. Departement of Microbiology St. Xavier’s College, Kanti Children’s Hospital, Departement of Microbiology Prithu Technical College, Nepal. Hlm. 1-6.
(15) World Health Organization. 2012. Recommendations for Management of Common Childhood Conditions. WHO. Hlm. 23-24, 26-29.
(16) Tzialla C, Borghesi A, Serra G, Stronati M, Corsello G. 2015. Antimicrobial Theraphy in Neonatal Intensive Care Unit. Dalam: Italian Journal of Pediatrics. Neonatologia, Patologia Neonatale E Terapia Intensive Neonatale, Fondazione IRCCS Policlinico San Matteo, Pavia, Italia. Hlm. 1-6.
(17) Waltner-Toews RI, Paterson DL, Qureshi ZA, Sidjabat HE, Adams-Haduch JM, Shutt KA, Jones M, Tian GB, Pasculle AW, Doi Y. 2011. Clinical Characteristics of Bloodstream Infections due to Ampicillin-Sulbactam-Resistant, Non-Extended-Spectrum-Beta-Lactamase-Producing Eschericia coli and the role of TEM-1 Hyperproduction. Dalam: Journal of Antimicrobial Agents Chemotheraphy. Division of Infectious Diseases, University of Pittsburgh Medical Center, United States of America. Hlm. 1.
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(19) Seale AC, Obiero CW, Berkley JA. 2015. Rational Development of Guidelines for Management of Neonatal Sepsis in Developing Countries. Dalam: Journal of Current Opinion in Infectious Diseases. Departement of Infectious Diseases Informatics, University of Oxford, United Kingdom. Hlm. 1.
(20) Lead Nurse Neonatal and Pediatric Services. 2016. Sepsis Management Guideline for Neonates. Northern Devon Healthcare. Hlm. 1-21.
(21) Hayatullah MK, Tjipta GD, Sianturi P, Azlin E, Lubis BM, Syamsidah, Wahyuni F. 2017. Terapi Antibiotika Empiris pada Neonatus. Dalam: Majalah Kedokteran Nusantara Volume 50 No 2. Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara dan Rumah Sakit Umum Pusat Haji Adam Malik Medan, Medan. Hlm. 1-5.
(22) Cunha BA. 2014. Esensial Antibiotik. Penerbit Buku Kedokteran EGC. Jakarta. Hlm. 11.
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Published
2022-12-01
How to Cite
Panca, P. P. B. C., Priyanto, & Rahmi, N. . (2022). EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN SEPSIS NEONATUS DI RAWAT INAP PERINATOLOGI RSUD TARAKAN. Jurnal Farmamedika (Pharmamedika Journal), 7(2), 64–74. https://doi.org/10.47219/ath.v7i2.158
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