PERBANDINGAN INHIBISI BRUSEIN D TERHADAP PROTEIN NFKB PADA SEL KANKER PANKREAS SECARA FLEKSIBEL DAN RIGID DOCKING

Authors

  • Harry Noviardi Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
  • Armi Wulanawati Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor
  • Muhammad Sholehuddin malik Ibrohim Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor

DOI:

https://doi.org/10.47219/ath.v2i2.34

Keywords:

bruceine D, docking, pancreatic cancer, NFĸB protein

Abstract

Pancreatic cancer is a malignant tumor types are particularly deadly. Patients with pancreatic cancer are generally treated with chemoradiotherapy and gemcitabine, but still provide a good clinical outcome. This study aims to determine the ratio of the potential of bruceine D as inhibitors of protein NF?B transcription of pancreatic cancer cells by the Gibbs free energy (?G), inhibition constants, hydrogen interactions are flexible and rigid docking. Based on the analysis docking, docking flexibly deliver better results than rigid. Additionally, bruceine D provides the potential for better inhibition than gemcitabine.

References

[1] Nakamura T, Masuda K, Harada S, Akioka K, Sako H. 2013.Pancreatic cancer: Slow progression in the early stages. Int JSurgery Case Rep. 4:693-696. [2] Zhao G, Deng S, Zhu S, Wang B, Li X, Liu Y, et al.2014.Chronic pancreatitis and pancreatic cancer demonstrate active epithelial-mesenchymal transition profile, regulated by miR-217-SIRT1 pathway. Cancer Lett. 355:184-191. [3] Pratheeshkumar P, Sreekala C, Budhraja A, Ding S, Son Y, Wang X, et al.2012. Cancer prevention with promising natural products: mechanisms of action and molecular targets. Anti-Cancer Agents in MedChem. 12:1-26. [4] Kuno T, Tsukamoto T, Hara A, Tanaka T. 2012. Cancer chemoprevention trough the introduction of apoptosis by natural compound. Journal of Biophysical Chemistry. 2:156-173 [5] Yan C, Siegel D, Newsome J, Chiloux A, Moody CJ, Ross D. 2012. Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling. Molecular Pharmacology. 81(3):401-410. [6] Lin L, Leung PS. 2014.Use herbal medicines and natural product: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer. Int JBiochem & Cell Bio. 53:224-236.

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Published

2017-12-12

How to Cite

Harry Noviardi, Armi Wulanawati, & Muhammad Sholehuddin malik Ibrohim. (2017). PERBANDINGAN INHIBISI BRUSEIN D TERHADAP PROTEIN NFKB PADA SEL KANKER PANKREAS SECARA FLEKSIBEL DAN RIGID DOCKING. Jurnal Farmamedika (Pharmamedica Journal), 2(2), 55–62. https://doi.org/10.47219/ath.v2i2.34

Issue

Vol. 2 No. 2 (2017): Jurnal Farmamedika (Pharmamedica Journal)

Section

Articles