KARAKTERISASI NANOVESIKEL TRANSFERSOM SEBAGAI PEMBAWA “RUTIN” DALAM PENGEMBANGAN SEDIAAN TRANSDERMAL

  • Devi Ratnasari Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
  • Effionora Anwar Departemen Farmasetika, Fakultas Farmasi, Universitas Indonesia
Keywords: Flavonoid, Nanovesicle, Rutin, Transdermal, Transfersom

Abstract

Transdermal become the alternative to deliver low solubility compound and low bioavalibility when given orally. Rutin is a flavonoid compound are found in watermelon and citrus. Rutin shows a low absorption when administered orally so the alternative is given in the transdermal route. A variety of approaches taken to increase the penetration of transdermal, one with nanovesikel carrier system. Transfersome is nanovesicle 200-300 nm sized composed of phospholipids, surfactants and water to increase penetration in trasndermal route. This study was to characterization transfersome containing rutin. The result show the size of transfersome < 150 nm, polydispersity index about 0.1 to 0.3, zeta potential less than -30 mV and entrapment efficiency > 80%.

References

[1] Prajapati, S.T., Patel, C.G., Patel, C.N. 2011. Transfersomes: A Vesicular Carrier System for Transdermal Drug Delivery. Asian Journal of Biochemical and Pharmaceutical Research. 2 (1): 121-128.
[2] Zielinska, D., Nowak, D.S., Zielinski, H. 2010. Determination of The Antioxidant Activity of Rutin and its Contribution to The Antioxidant Capacity of Diversifed Buckwheat Origin Material by Updated Analytical Strategies. Polish Journal of Food and Nutrition Sciences. 40: 315-321
[3] Manach, C., Morand, C., Demigne, C., Texier, O, Regerat, F., Remesy, C. 1997. Bioavailability of Rutin and Quercetin in Rats. FEBS Letters. 409: 12-16.
[4] Mauludin, R., Muller, R.H., Keck, C.M. 2008. Kinetic Solubility and Dissolution Velocity of Rutin Nanocrystals. European Journal of Pharmaceutical Science. 36:502-510.
[5] Shimoi, K., Yoshizumi,K., Kido, T., Usui, Y., Yumoto, T. 2003. Absorption and Urinary Excretion of Quercetin, Rutin and α-G-Rutin, a Water Soluble Flavonoid in Rats. Journal of Agricultural and Food Chemistry. 51: 2785-2789.
[6] Walve, J.R., Bakliwal, S.R., Rane B.R., Pawar S.P. 2011. Transfersomes: A Surrogated Carrier for Transdermal Drug Delivery System. International Journal of
(a)
(b)
(c) Applied Biology and Pharmaceutical Technology. 2(1).
[7] Gupta, P.N., Mishra, V., Rawat, A., Dubey, P., Mahor, S., Jain, S., Chatterji, D.P., Vyas, S.P. 2005. Non-Invasive Vaccine Delivery in Transfersomes, Niosomes and Liposomes: a Comparative Study. International Journal of Pharmaceutic. 293: 73-82.
[8] Varshneya, A., Ravikumar, P. 2015. Formulation and Characterization of Rutin Trihydrate Liposomes for Topical Delivery. Internaional Journal of Pharmaceutical Research.
[9] Taurozzi, J.S., Hackley, V.A., Wiesner, M.R. 2010. Protocol for Preparation Nanoparticle Dispersion from Powdered Material Using Ultrasonic Disruption. National Institute for Standard and Technology. United State of America.
[10] Hadian, Z., Sahari, M., Moghimi, H.R., Barzegar, M. 2014. Formulation, Characterization and Optimation of Liposome Containing Eicosapentaenoic and Docosahexaenoic Acids; a Methodology Approach. International Journal of Pharmaceutical Research, 13 (2): 393-404.
[11] Barry, Brian., W, Elka., Couitoo. 2007. Enhancement in Drug Delivery. CRC Press, Taylor & Francis Group. United States
[12] Saraf, S., Jeswani, G., Kaur, C.D., Saraf, S. (2011). Development of Herbal Cosmetic Cream With Curcuma Longa Extract Loaded Transfersomes for Antiwrinkle Effect. African : 1056-106
Published
2019-11-07
How to Cite
Devi Ratnasari, & Effionora Anwar. (2019). KARAKTERISASI NANOVESIKEL TRANSFERSOM SEBAGAI PEMBAWA “RUTIN” DALAM PENGEMBANGAN SEDIAAN TRANSDERMAL. Farmamedika (Pharmamedika Journal), 1(1), 12-18. Retrieved from https://ejournal.sttif.ac.id/index.php/farmamedika/article/view/40