PERBANDINGAN INHIBISI α-MANGOSTIN, β-MANGOSTIN, DAN γ-MANGOSTIN TERHADAP PROTEIN AKT-KINASE PADA SEL KANKER PANKREAS SECARA MOLECULAR DOCKING

  • Harry Noviardi Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
  • Armi Wulanawati Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor
  • Muhamad Sholehuddin Malik Ibrohim Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor
Keywords: Akt protein, docking, pancreatic cancer, α-mangostin, β-mangostin, γ-mangostin

Abstract

The mangosteen pericarp contains a class of compounds called xanthones, including α-mangostin, β-mangostin, and, γ-mangostin. Mangosteen products have become popular natural medicine. cancer is a malignant tumor types are particularly deadly caused by proliferative effects to inhibit apoptosis cell. Akt protein is considered to be the key downstream effector of reducing apoptosis. This study aims to determine the ratio of the potential of α-mangostin, β-mangostin, γ-mangostin as inhibitors of Akt protein of pancreatic cancer cells by the Gibbs free energy (ΔG), inhibition constants, hydrogen interactions. The computationally study using molecular docking method.Based on the analysis docking, γ-mangostin provides the potential for better inhibition than gemcitabine.

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Published
2016-06-13
How to Cite
Harry Noviardi, Armi Wulanawati, & Muhamad Sholehuddin Malik Ibrohim. (2016). PERBANDINGAN INHIBISI α-MANGOSTIN, β-MANGOSTIN, DAN γ-MANGOSTIN TERHADAP PROTEIN AKT-KINASE PADA SEL KANKER PANKREAS SECARA MOLECULAR DOCKING. Jurnal Farmamedika (Pharmamedika Journal), 1(1), 34-40. https://doi.org/10.47219/ath.v1i1.43